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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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SLC5A11 / SMIT2
solute carrier family 5 (sodium/inositol cotransporter), member 11
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na+:MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.
| Gene Name: | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
| Family/Subfamily: | Transporter , Solute:sodium symporter |
| Synonyms: | SLC5A11, Homolog of rabbit KST1, KST1, SLGTX, SMIT2, RKST1, SGLT6 |
| Target Sequences: | NM_052944 NP_443176.2 Q8WWX8 |
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