SLC4A1 / Band 3 / AE1

solute carrier family 4 (anion exchanger), member 1 (Diego blood group)

SLC4A1 / Band 3 / AE1 is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

SLC4A1 / Band 3 / AE1 (8)

Publications

No (8)

Tag

10His, N-terminus + Myc, C-terminus (1)

10His-SUMO, N-terminus + Myc, C-terminus (1)

GST, N-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

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Human SLC4A1 / Band 3 / AE1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74701

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

101.6 kDa

Price:

20 µg/$215

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Human SLC4A1 / Band 3 / AE1 Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa1-403) - LS-G56528

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SLC4A1 / Band 3 / AE1 Protein (Recombinant GST, N-terminus) (aa261-360) - LS-G60113

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SLC4A1 / Band 3 / AE1 Protein (Recombinant His-T7) (aa35-290) - LS-G14137

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.1 kDa

Price:

10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219

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Human SLC4A1 / Band 3 / AE1 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (aa1-403) - LS-G56531

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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SLC4A1 / Band 3 / AE1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123255

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

101.6 kDa

Price:

100 µg/$710

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Rat SLC4A1 / Band 3 / AE1 Protein (Recombinant His) (aa558-675) - LS-G24423

Source:

E. coli

Tag:

His

Molecular Weight:

16.9 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human SLC4A1 / Band 3 / AE1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65038

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

101.6 kDa

Price:

20 µg/$1,107

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