SLC46A1 / HCP1

solute carrier family 46 (folate transporter), member 1

SLC46A1 / HCP1 is a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

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Proteins (2)

Type

Over-Expression Lysate (2)

Target

SLC46A1 / HCP1 (2)

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No (2)

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Myc-DDK (Flag) (2)

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Human (1)

Source

293T Cells (1)

HEK 293 Cells (1)

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Human SLC46A1 / HCP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92798

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.8 kDa

Price:

20 µg/$215

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SLC46A1 / HCP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107760

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.8 kDa

Price:

100 µg/$710

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