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SLC40A1 / Ferroportin-1

solute carrier family 40 (iron-regulated transporter), member 1

May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

Gene Name: solute carrier family 40 (iron-regulated transporter), member 1
Family/Subfamily: Transporter , Natural resistance-associated macrophage protein (NRAMP)
Synonyms: SLC40A1, Ferroportin, FPN1, Iron-regulated transporter 1, MST079, MSTP079, IREG1, Iron regulated gene 1, SLC11A3, MTP1, Ferroportin-1, HFE4
Target Sequences: NM_014585 NP_055400.1 Q9NP59

Publications (8)

1
Intestinal ferritin H is required for an accurate control of iron absorption. Vanoaica L, Darshan D, Richman L, Schmann K, Khn LC. Cell metabolism. 2010 12:273-82. [PubMed:20816093]
2
mTOR regulates cellular iron homeostasis through tristetraprolin. Bayeva M, Khechaduri A, Puig S, Chang HC, Patial S, Blackshear PJ, Ardehali H. Cell metabolism. 2012 16:645-57. (WB; Mouse) [PubMed:23102618] [PMC:PMC3594686]
3
Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia. Chandran V, Gao K, Swarup V, Versano R, Dong H, Jordan MC, Geschwind DH,. eLife. 2017 6: (WB; Human) [Full Text Article] [PubMed:29257745] Related Antibodies: LS-B1836.
4
Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction. Ross SL, Biswas K, Rottman J, Allen JR, Long J, Miranda LP, Winters A, Arvedson TL. Frontiers in pharmacology. 2017 8:838. (WB; Human) [Full Text Article] [PubMed:29209212] Related Antibodies: LS-B1836.
5
Increased Duodenal Iron Absorption through Upregulation of Ferroportin 1 due to the Decrement in Serum Hepcidin in Patients with Chronic Hepatitis C. Sato M, Miyanishi K, Tanaka S, Sakurada A, Sakamoto H, Kawano Y, Takada K, Kobune M, Kato J. Canadian journal of gastroenterology & hepatology. 2018 August;2018:2154361. [Full Text Article] [PubMed:30186818] [PMC:PMC6112088] Related Antibodies: LS-B1836.
6
Extracellular Vesicles Reveal Abnormalities In Neuronal Iron Metabolism In Restless Legs Syndrome. Sahil Chawla, Seema Gulyani, Richard P Allen, Christopher J Earley, Xu Li, Peter Van Zijl, Dimitrios Kapogiannis. Sleep. 2019 March; [Full Text Article] [PubMed:30895312] [PMC:PMC6612672]
7
Unbalance in Iron Metabolism in Childhood Leukemia Converges with Treatment Intensity: Biochemical and Clinical Analysis. Monika Lecka, Artur Slomka, Katarzyna Albrecht, Ewa Zekanowska, Michal Romiszewski, Jan Styczynski. Cancers. 2021 June;13:3029. [Full Text Article] [PubMed:34204310] [PMC:PMC8233795]
8
Neonatal iron overload and tissue siderosis due to gestational alloimmune liver disease. Bonilla S, Prozialeck JD, Malladi P, Pan X, Yu S, Melin-Aldana H, Whitington PF. Journal of hepatology. 2014 Jun;56:1351-5. [Full Text Article] [PubMed:22322235] Related Antibodies: LS-B1836.
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).