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SLC30A8 / ZNT8

solute carrier family 30 (zinc transporter), member 8

SLC30A8 / ZNT8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.

Gene Name: solute carrier family 30 (zinc transporter), member 8
Family/Subfamily: Transporter , Cation diffusion facilitator
Synonyms: SLC30A8, ZNT8, Zinc transporter 8, Zinc transporter ZnT-8, ZnT-8
Target Sequences: NM_001172811 NP_001166282.1 Q8IWU4

Publications (1)

1
Presence of diabetes autoantigens in extracellular vesicles derived from human islets. Hasilo CP, Negi S, Allaeys I, Cloutier N, Rutman AK, Gasparrini M, Bonneil É, Thibault P, Boilard É, Paraskevas S. Scientific reports. 2017 7:5000. (ICC, WB, Flo; Human, Hamster) [Full Text Article] [PubMed:28694505] [PMC:PMC5504025] Related Antibodies: LS-C303154.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
SLC30A8 / ZNT8 (5)
No (5)
10His, N-terminus (1)
His, N-Terminal (2)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Purified (2)
SLC30A8 / ZNT8 Protein - Recombinant Solute Carrier Family 30 Member 8 By SDS-PAGE
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E. coli
His, N-Terminal
13.3 kDa
10 µg/$339; 50 µg/$802; 100 µg/$1,214; 200 µg/$1,430; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988
SLC30A8 / ZNT8 Protein - Recombinant Solute Carrier Family 30 Member 8 By SDS-PAGE
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E. coli
His, N-Terminal
10.7 kDa
10 µg/$274; 50 µg/$400; 100 µg/$637; 200 µg/$797; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053
SLC30A8 / ZNT8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
40.6 kDa
100 µg/$494
Select
E. coli
10His, N-terminus
43.6 kDa
100 µg/$1,801; 20 µg/$1,247
SLC30A8 / ZNT8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
40.6 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).