SLC29A4

solute carrier family 29 (equilibrative nucleoside transporter), member 4

Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.

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Proteins (5)

Type

Over-Expression Lysate (4)

Recombinant (1)

Target

SLC29A4 (5)

Publications

No (5)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human SLC29A4 Protein (Recombinant GST, N-terminus) (aa283-345) - LS-G63834

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SLC29A4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93572

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.9 kDa

Price:

20 µg/$215

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Human SLC29A4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93573

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.9 kDa

Price:

20 µg/$150

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SLC29A4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105894

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.9 kDa

Price:

100 µg/$494

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SLC29A4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120368

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.9 kDa

Price:

100 µg/$710

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