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SLC26A8 / TAT1
solute carrier family 26 (anion exchanger), member 8
Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.
| Gene Name: | solute carrier family 26 (anion exchanger), member 8 |
| Family/Subfamily: | Transporter , Sulfate transporter |
| Synonyms: | SLC26A8, Anion exchange transporter, Anion transporter/exchanger-8, Testis anion transporter 1, TAT1 |
| Target Sequences: | NM_052961 NP_443193.1 Q96RN1 |
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