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SLC22A5 / OCTN2

solute carrier family 22 (organic cation/carnitine transporter), member 5

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants.

Gene Name: solute carrier family 22 (organic cation/carnitine transporter), member 5
Family/Subfamily: Transporter , Organic cation transporter
Synonyms: SLC22A5, CDSP, OCTN2VT, OCTN2, UST2
Target Sequences: NM_003060 NP_003051.1 O76082

Publications (1)

1
Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. Kim HI, Raffler J, Lu W, Lee JJ, Abbey D, Saleheen D, Rabinowitz JD, Bennett MJ, Hand NJ, Brown C, Rader DJ. American journal of human genetics. 2017 October;101:489-502. (Mouse) [Full Text Article] [PubMed:28942964] [PMC:PMC5630162] Related Antibodies: LS-C313281.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
SLC22A5 / OCTN2 (4)
No (4)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
SLC22A5 / OCTN2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SLC22A5 / OCTN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
62.6 kDa
20 µg/$150
SLC22A5 / OCTN2 Protein - 12.5% SDS-PAGE of human SLC22A5 stained with Coomassie Blue
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Wheat Germ Extract
GST
89.1 kDa
2 µg/$439
SLC22A5 / OCTN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
62.6 kDa
100 µg/$494
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).