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SLC22A2
solute carrier family 22 (organic cation transporter), member 2
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.
| Gene Name: | solute carrier family 22 (organic cation transporter), member 2 |
| Family/Subfamily: | Transporter , Organic cation transporter |
| Synonyms: | SLC22A2, HOCT2, OCT2, Organic cation transporter 2 |
| Target Sequences: | NM_003058 NP_003049.2 O15244 |
Publications (2)
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