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SLC22A2

solute carrier family 22 (organic cation transporter), member 2

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.

Gene Name: solute carrier family 22 (organic cation transporter), member 2
Family/Subfamily: Transporter , Organic cation transporter
Synonyms: SLC22A2, HOCT2, OCT2, Organic cation transporter 2
Target Sequences: NM_003058 NP_003049.2 O15244

Publications (2)

1
The Role of NF-kB in the Downregulation of Organic Cation Transporter 2 Expression and Renal Cation Secretion in Kidney Disease. Chao Han, Juan Zheng, Fengyi Wang, Qingyang Lu, Qingfa Chen, Ankang Hu, Michele Visentin, Gerd A Kullak-Ublick, Zhibo Gai, Lei Chu. Frontiers in medicine. 2022 January;8:800421. [Full Text Article] [PubMed:35059420] [PMC:PMC8763702] Related Antibodies: LS-C357581.
2
Renal PET-imaging with (11)C-metformin in a transgenic mouse model for chronic kidney disease. Pedersen L, Jensen JB, Wogensen L, Munk OL, Jessen N, Frøkiær J, Jakobsen S. EJNMMI research. 2016 6:54. (WB; Human) [Full Text Article] [PubMed:27339044] [PMC:PMC4919269] Related Antibodies: LS-C80615.

☰ Filters
Antibodies (28)
Proteins (4)
Over-Expression Lysate (2)
Primary (28)
Recombinant (2)
SLC22A2 (32)
Human (27)
Mouse (7)
Rat (11)
Chimpanzee (3)
Gibbon (3)
Guinea pig (3)
Orangutan (3)
Pig (3)
IHC (6)
IHC-P (6)
WB (23)
ELISA (10)
IF (1)
Peptide-ELISA (1)
rabbit (27)
mouse (1)
Product Group
IHCPlus (2)
IgG (21)
IgG2a (1)
monoclonal mc (1)
polyclonal pc (27)
11n175 (1)
APC Conjugated (1)
Azide-free (2)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (17)
aa514-541 (7)
N-Terminus (4)
C-Terminus (2)
aa524-555 (1)
aa57-89 (1)
No (30)
Yes (2)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
SLC22A2 Antibody - SLC22A2 antibody IHC-paraffin: Mouse Kidney Tissue.
Select
SLC22A2 Rabbit anti-Human Polyclonal (aa524-555) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SLC22A2 Antibody - Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC22A2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
SLC22A2 Antibody - Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC22A2 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Guinea pig, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human
WB
HRP Conjugated
100 µl/$442
SLC22A2 Antibody - Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC22A2 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Guinea pig, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human
WB
Biotin Conjugated
100 µl/$442
SLC22A2 Antibody - Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC22A2 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Guinea pig, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human
WB
FITC Conjugated
100 µl/$442
SLC22A2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SLC22A2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SLC22A2 Antibody - Immunohistochemistry image of paraffin-embedded human endometrial cancer at a dilution of 1:100
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SLC22A2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
SLC22A2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, WB
Unconjugated
100 µg/$832
SLC22A2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SLC22A2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SLC22A2 Antibody - Antibody staining SLC22A2 in human stomach tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH 6). Samples were incubated with primary antibody (1:25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
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SLC22A2 Rabbit anti-Human Polyclonal (aa57-89) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
200 µl/$393
SLC22A2 Antibody - IHC testing of FFPE mouse kidney with SLC22A2 antibody. HIER: Boil the paraffin sections in pH 6, 10mM citrate buffer for 20 minutes and allow to cool prior to staining.
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SLC22A2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
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SLC22A2 Rabbit anti-Human Polyclonal (aa514-541) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
SLC22A2 Rabbit anti-Human Polyclonal (aa514-541) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
SLC22A2 Rabbit anti-Human Polyclonal (aa514-541) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
SLC22A2 Rabbit anti-Human Polyclonal (aa514-541) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
SLC22A2 Rabbit anti-Human Polyclonal (aa514-541) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
SLC22A2 Rabbit anti-Human Polyclonal (aa514-541) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
SLC22A2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
Select
SLC22A2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
Select
SLC22A2 Mouse anti-Human Monoclonal (Azide-free) (11n175) Antibody
Human
IHC
Unconjugated, Azide-free
100 µg/$896
Select
SLC22A2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
Select
SLC22A2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
SLC22A2 Antibody - SLC22A2 Antibody western blot of CEM cell line lysates (35 ug/lane). The SLC22A2 antibody detected the SLC22A2 protein (arrow).
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SLC22A2 Rabbit anti-Human Polyclonal (aa514-541) Antibody
Human
WB
Unconjugated
400 µl/$393
SLC22A2 Antibody - Western blot analysis of extracts of mouse kidney using SLC22A2 Polyclonal Antibody at dilution of 1:1000.
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SLC22A2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
SLC22A2 Antibody - Western blot analysis of extracts of mouse kidney, using SLC22A2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Select
SLC22A2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
Viewing 1-25 of 32 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).