SLC22A1

solute carrier family 22 (organic cation transporter), member 1

Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.

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Products

ELISA Kits (6)

Type

Custom (4)

DNA Binding (1)

Sandwich (1)

Target

SLC22A1 (6)

Reactivity

Human (2)

Mouse (2)

Rat (1)

Bovine (1)

Pig (1)

Format

12 x 8-Well Microstrips (1)

96-Well Strip Plate (5)

Publications

No (6)

Sample Type

Cell Lysates (1)

Nuclear Lysates (1)

Plasma (1)

Serum (1)

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Human SLC22A1 (Sandwich ELISA) ELISA Kit - LS-F66548

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Bovine SLC22A1 (Custom) ELISA Kit - LS-F65670

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Price:

1 Plate/$783

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Mouse SLC22A1 (Custom) ELISA Kit - LS-F66229

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

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Rat SLC22A1 (Custom) ELISA Kit - LS-F66205

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$783

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Pig SLC22A1 (Custom) ELISA Kit - LS-F65741

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Price:

1 Plate/$783

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Mouse/Human SLC22A1 (DNA-Binding ELISA) ELISA Kit - LS-F898

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

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