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SLC16A1 / MCT1

solute carrier family 16 (monocarboxylate transporter), member 1

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

Gene Name: solute carrier family 16 (monocarboxylate transporter), member 1
Family/Subfamily: Transporter , Monocarboxylic acid transporter
Synonyms: SLC16A1, MCT1, MCT, HHF7, Monocarboxylate transporter 1, MCT 1
Target Sequences: NM_003051 NP_003042.3 P53985

Publications (1)

1
Label-free sensing of exosomal MCT1 and CD147 for tracking metabolic reprogramming and malignant progression in glioma. A Thakur, G Qiu, C Xu, X Han, T Yang, S P Ng, K W Y Chan, C M L Wu, Y Lee. Science advances. 2020 June;6:eaaz6119. [Full Text Article] [PubMed:32637597] [PMC:PMC7319757]

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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
SLC16A1 / MCT1 (6)
No (6)
GST (1)
Myc-DDK (Flag) (5)
Human (4)
293T Cells (2)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (1)
SLC16A1 / MCT1 Protein - Purified recombinant protein SLC16A1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
53.8 kDa
20 µg/$1,107
SLC16A1 / MCT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
54.4 kDa
100 µg/$494
SLC16A1 / MCT1 Protein - 12.5% SDS-PAGE of human SLC16A1 stained with Coomassie Blue
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Wheat Germ Extract
GST
80.4 kDa
2 µg/$439
SLC16A1 / MCT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
54.4 kDa
20 µg/$150
SLC16A1 / MCT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
53.8 kDa
20 µg/$150
SLC16A1 / MCT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
53.8 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).