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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SLC12A1 / NKCC2

solute carrier family 12 (sodium/potassium/chloride transporter), member 1

SLC12A1 / NKCC2 is a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.

Gene Name: solute carrier family 12 (sodium/potassium/chloride transporter), member 1
Family/Subfamily: Transporter , Cation:chloride symporter
Synonyms: SLC12A1, BSC1, MBSC1, Na-K-2Cl cotransporter, NKCC2A variant A, RBSC, NKCC2
Target Sequences: NM_000338 NP_000329.2 Q13621

Publications (2)

1
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR. Human molecular genetics. 2015 24:4545-58. (WB; Human) [Full Text Article] [PubMed:25994507] [PMC:PMC4512625] Related Antibodies: LS-C313275.
2
Whole-exome resequencing reveals recessive mutations in TRAP1 in individuals with CAKUT and VACTERL association. Saisawat P, Kohl S, Hilger AC, Hwang DY, Yung Gee H, Dworschak GC, Tasic V, Pennimpede T, Natarajan S, Sperry E, Matassa DS, Staji[Character 107] N, Bogdanovic R, de Blaauw I, Marcelis CL, Wijers CH, Bartels E, Schmiedeke E, Schmidt D, M[Character e4]rzheuser S, Grasshoff-Derr S, Holland-Cunz S, Ludwig M, N[Character f6]then MM, Draaken M, Brosens E, Heij H, Tibboel D, Herrmann BG, Solomon BD, de Klein A, van Rooij IA, Esposito F, Reutter HM, Hildebrandt F. Kidney international. 2014 Jun;85:1310-7. [Full Text Article] [PubMed:24152966] [PMC:PMC3997628] Related Antibodies: LS-C150446.

Filtered By: None
Target
SLC12A1 / NKCC2 (49)
Reactivity
Human (48)
Mouse (36)
Rat (37)
Bat (4)
Bovine (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Horse (4)
Monkey (6)
Orangutan (3)
Pig (4)
Rabbit (5)
Application
IHC (19)
IHC-Fr (1)
IHC-P (4)
WB (48)
ELISA (4)
ICC (2)
Host
rabbit (47)
mouse (1)
goat (1)
Isotype
IgG (26)
IgG2a,k (1)
Clonality
monoclonal mc (1)
polyclonal pc (48)
Clone
4H4 (1)
Format
AP Conjugated (2)
APC (1)
APC Conjugated (3)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 565 Conjugated (1)
Atto 594 Conjugated (2)
Atto 633 Conjugated (1)
Atto 655 Conjugated (1)
Atto 680 Conjugated (1)
Atto 700 Conjugated (1)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (3)
PE (1)
PE Conjugated (2)
PerCP Conjugated (1)
RPE Conjugated (1)
SA Conjugated (1)
Unconjugated (15)
Epitope
aa33-55 (16)
aa814-1099 (10)
aa351-400 (4)
C-Terminus (2)
Cytoplasmic Domain (1)
N-Terminus (1)
aa125-139 (1)
aa43-57 (1)
aa52-83 (1)
Publications
No (47)
Yes (2)
Showing 1-25 of 49 results

SLC12A1 / NKCC2 Antibody (aa43-57) IHC-plus™ LS-B5131
Goat Polyclonal to Human SLC12A1 / NKCC2
Human, Monkey
IHC IHC-P
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-SLC12A1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-SLC12A1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.

SLC12A1 / NKCC2 Antibody (aa125-139) LS-C313275
Publications (1)
Publications (1)
Rabbit Polyclonal to Human SLC12A1 / NKCC2
Mouse, Rat, Human
IHC IHC-Fr IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $355.00
SLC12A1 / NKCC2 antibody. IHC(F): Rat Kidney Tissue.
SLC12A1 / NKCC2 antibody. IHC(P): Rat Kidney Tissue.
SLC12A1 / NKCC2 antibody. IHC(F): Rat Kidney Tissue.
SLC12A1 / NKCC2 antibody. IHC(P): Rat Kidney Tissue.

SLC12A1 / NKCC2 Antibody LS-C150446
Publications (1)
Publications (1)
Rabbit Polyclonal to Rat SLC12A1 / NKCC2
Mouse, Rat, Human
WB
Unconjugated
100µg 1mg/ml  $375.00
Western blot analysis of NKCC2 in rat kidney tissue using a 1:1000 dilution of SLC12A1 / NKCC2 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot analysis of NKCC2 in rat kidney tissue using a 1:1000 dilution of SLC12A1 / NKCC2 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SLC12A1 / NKCC2 Antibody (aa33-55, PE, Atto 594) LS-C229744
Rabbit Polyclonal to Rat SLC12A1 / NKCC2
Mouse, Rat, Human
WB
PE, Atto 594 Conjugated
100µg 1mg/ml  $415.00
Western blot analysis of NKCC2 in rat kidney tissue using a 1:1000 dilution of SLC12A1 / NKCC2 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot analysis of NKCC2 in rat kidney tissue using a 1:1000 dilution of SLC12A1 / NKCC2 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SLC12A1 / NKCC2 Antibody (C-Terminus) LS-C16866
Rabbit Polyclonal (IgG) to Rat SLC12A1 / NKCC2
Rat
ELISA IHC WB
Unconjugated
50µg 1mg/ml  $445.00; 100µg  $755.00

SLC12A1 / NKCC2 Antibody (aa351-400) LS-C40323
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IHC WB
Unconjugated
50µg  $365.00
A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SLC12A1 / NKCC2 Antibody (aa351-400, HRP) LS-C442084
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SLC12A1 / NKCC2 Antibody (aa351-400, Biotin) LS-C442082
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC WB
Biotin Conjugated
100µl 1mg/ml  $385.00
A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SLC12A1 / NKCC2 Antibody (aa351-400, FITC) LS-C442081
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC WB
FITC Conjugated
100µl 1mg/ml  $385.00
A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SLC12A1 / NKCC2 Antibody (aa52-83) LS-C357580
Rabbit Polyclonal to Human SLC12A1 / NKCC2
Mouse, Rat, Human, Monkey
IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $325.00
SLC12A1 antibody IHC-paraffin: Mouse Kidney Tissue.
SLC12A1 antibody IHC-paraffin: Rat Kidney Tissue.
SLC12A1 antibody IHC-paraffin: Mouse Kidney Tissue.
SLC12A1 antibody IHC-paraffin: Rat Kidney Tissue.

SLC12A1 / NKCC2 Antibody LS-C404285
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human colon cancer using SLC12A1 Polyclonal Antibody at dilution of 1:15.
Immunohistochemistry of Human brain using SLC12A1 Polyclonal Antibody at dilution of 1:15.
Immunohistochemistry of Human colon cancer using SLC12A1 Polyclonal Antibody at dilution of 1:15.
Immunohistochemistry of Human brain using SLC12A1 Polyclonal Antibody at dilution of 1:15.

SLC12A1 / NKCC2 Antibody LS-C490071
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µg  $365.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

SLC12A1 / NKCC2 Antibody LS-C342254
Rabbit Polyclonal to Human SLC12A1 / NKCC2
Mouse, Rat, Human
IHC WB
Unconjugated
100µl 1mg/ml  $385.00

SLC12A1 / NKCC2 Antibody (aa814-1099) LS-C373263
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
Western blot of SLC12A1 / NKCC2 antibody.
Western blot of SLC12A1 / NKCC2 antibody.

SLC12A1 / NKCC2 Antibody (aa814-1099, HRP) LS-C713006
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Human
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $680.00; 10ml  $2,730.00
Western blot of SLC12A1 / NKCC2 antibody.
Western blot of SLC12A1 / NKCC2 antibody.

SLC12A1 / NKCC2 Antibody (aa814-1099, Biotin) LS-C423542
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Human
ICC WB
Biotin Conjugated
100µl 0.5mg/ml  $375.00

SLC12A1 / NKCC2 Antibody (aa814-1099, Biotin) LS-C688299
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Human
IHC WB
Biotin Conjugated
20µl  $205.00; 100µl  $265.00; 200µl  $315.00; 1ml  $575.00; 10ml  $2,310.00
Western blot of SLC12A1 / NKCC2 antibody.
Western blot of SLC12A1 / NKCC2 antibody.

SLC12A1 / NKCC2 Antibody (aa814-1099, FITC) LS-C423543
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Human
ICC WB
FITC Conjugated
100µl 0.5mg/ml  $395.00

SLC12A1 / NKCC2 Antibody (aa814-1099, FITC) LS-C695233
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Human
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
Western blot of SLC12A1 / NKCC2 antibody.
Western blot of SLC12A1 / NKCC2 antibody.

SLC12A1 / NKCC2 Antibody (aa814-1099, PE) LS-C727069
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Human
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
Western blot of SLC12A1 / NKCC2 antibody.
Western blot of SLC12A1 / NKCC2 antibody.

SLC12A1 / NKCC2 Antibody (aa814-1099, APC) LS-C741323
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Human
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $305.00; 200µl  $375.00; 1ml  $785.00
Western blot of SLC12A1 / NKCC2 antibody.
Western blot of SLC12A1 / NKCC2 antibody.

SLC12A1 / NKCC2 Antibody (aa814-1099, APC, Cy7) LS-C735995
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Human
IHC WB
APC, Cy7 Conjugated
20µl  $285.00; 100µl  $455.00; 200µl  $635.00; 1ml  $1,575.00; 10ml  $6,300.00
Western blot of SLC12A1 / NKCC2 antibody.
Western blot of SLC12A1 / NKCC2 antibody.

SLC12A1 / NKCC2 Antibody (aa814-1099, Cy3) LS-C703986
Rabbit Polyclonal (IgG) to Human SLC12A1 / NKCC2
Human
IHC WB
Cy3 Conjugated
20µl  $245.00; 100µl  $355.00; 200µl  $445.00; 1ml  $1,050.00; 10ml  $4,200.00
Western blot of SLC12A1 / NKCC2 antibody.
Western blot of SLC12A1 / NKCC2 antibody.

SLC12A1 / NKCC2 Antibody (clone 4H4) LS-C198215
Mouse Monoclonal [clone 4H4] (IgG2a,k) to Human SLC12A1 / NKCC2
Human
ELISA WB
Unconjugated
100µg  $355.00
Western Blot analysis of SLC12A1 expression in transfected 293T cell line by SLC12A1 monoclonal antibody (M03), clone 4H4.Lane 1: SLC12A1 transfected lysate(46.5 KDa).Lane 2: Non-transfected lysate.
Western Blot analysis of SLC12A1 expression in transfected 293T cell line by SLC12A1 monoclonal antibody (M03), clone 4H4.Lane 1: SLC12A1 transfected lysate(46.5 KDa).Lane 2: Non-transfected lysate.

SLC12A1 / NKCC2 Antibody (C-Terminus) LS-C16867
Rabbit Polyclonal (IgG) to Rat SLC12A1 / NKCC2
Rabbit, Mouse, Rat, Human
ELISA WB
Unconjugated
100µl  $725.00
Showing 1-25 of 49 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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