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SLC11A2 / DMT1

solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2

Solute carrier family 11, member 2 (SLCA2) also known as divalent metal ion transporter 1 (DMT1) imports Fe2+ via a proton-coupled, membrane potential dependent manner. It can also transport a variety of other divalent metal cations including Mn2+, Co2+, Cu2+, and Zn2+ but iron appears to be its most important physiological substrate. SLC11A2 has been demonstrated on the apical membrane of duodenal enterocytes, transferrin cycle endosomes in erythroid precursors, hepatocytes where it has been postulated to be involved in non-transferrin-bound iron uptake, and placenta where it has been implicated in transfer of iron from mother to fetus.

Gene Name:	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Family/Subfamily:	Transporter , Natural resistance-associated macrophage protein (NRAMP)
Synonyms:	SLC11A2, Divalent metal transporter 1, Divalent cation transporter 1, DMT-1, NRAMP 2, NRAMP2, Dct-1, DCT1, DMT1
Target Sequences:	NM_000617 NP_000608.1 P49281

Publications (1)

Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. Straud S, Zubovych I, De Brabander JK, Roth MG. PloS one. 2010 5:e11629. (WB; Human) [Full Text Article] [PubMed:20661293] [PMC:PMC2905441] Related Antibodies: LS-C16687.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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