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SLAMF1 / SLAM / CD150

signaling lymphocytic activation molecule family member 1

High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

Gene Name:	signaling lymphocytic activation molecule family member 1
Synonyms:	SLAMF1, CD150 antigen, CD150, IPO-3, SLAM, CDw150
Target Sequences:	NM_003037 NP_003028.1 Q13291

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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