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SKP2

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

SKP2 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.

Gene Name: S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Synonyms: SKP2, F-box/LRR-repeat protein 1, FBL1, FLB1, F-box protein Skp2, FBXL1, p45, p45skp2
Target Sequences: NM_005983 NP_005974.2 Q13309

Publications (3)

1
The Impact of SKP2 Gene Expression in Chronic Myeloid Leukemia. Hossam Hodeib, Dina Abd El Hai, Mohamed A Tawfik, Alzahraa A Allam, Ahmed F Selim, Mohamed E Sarhan, Amal Selim, Nesreen M Sabry, Wael Mansour, Amira Youssef. Genes. 2022 May;13: [Full Text Article] [PubMed:35741710] [PMC:PMC9223289]
2
Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop. Leilei Qi, Reka Chakravarthy, Monica M Li, Chu-Xia Deng, Rong Li, Yanfen Hu. iScience. 2022 September;25:104944. [Full Text Article] [PubMed:36065181] [PMC:PMC9440284] Related Antibodies: LS-B2487.
3
Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Parameswaran B, Chiang HC, Lu Y, Coates J, Deng CX, Baer R, Lin HK, Li R, Paull TT, Hu Y. Cell cycle (Georgetown, Tex.). 2015 14:437-48. [Full Text Article] [PubMed:25659039] Related Antibodies: LS-B2487.

☰ Filters
Products
Antibodies (60)
Primary (60)
SKP2 (60)
Human (58)
Mouse (12)
Rat (8)
Bovine (4)
Chimpanzee (3)
Gibbon (3)
Monkey (3)
Pig (4)
IHC (28)
IHC-P (15)
WB (54)
Flo (2)
ELISA (23)
ICC (5)
IF (10)
IP (16)
Peptide-ELISA (2)
rabbit (50)
mouse (10)
Product Group
IHCPlus (3)
IgG (28)
IgG1 (4)
IgG1,k (6)
monoclonal mc (10)
polyclonal pc (50)
6G9D10 (2)
SKP2-8D9 (1)
APC (1)
APC Conjugated (3)
Biotin Conjugated (6)
Concentrated (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
Magnetic beads Conjugated (1)
PE Conjugated (3)
Preservative Free (2)
Sepharose Conjugated (1)
Unconjugated (34)
aa43-397 (8)
C-Terminus (5)
N-Terminus (4)
aa1-424 (4)
aa2-20 (2)
340-420 aa, C-terminal (1)
Amino Acid: 1-130 (1)
Pro399 (1)
aa1-50 (1)
aa156-185 (1)
aa221-425 (1)
aa366-415 (1)
aa50-100 (1)
No (59)
Yes (1)
SKP2 Antibody - Anti-SKP2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SKP2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
SKP2 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SKP2/p45 Antibody. The picture on the right is blocked with the synthesized peptide.
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SKP2 Rabbit anti-Human Polyclonal (aa366-415) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
SKP2 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SKP2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$380
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SKP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$740
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SKP2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$982
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SKP2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$982
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SKP2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$982
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SKP2 Rabbit anti-Human Polyclonal (APC) Antibody
Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$982
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SKP2 Rabbit anti-Human Polyclonal (PE) Antibody
Human
ELISA, IHC, IP, WB
PE Conjugated
100 µl/$982
SKP2 Antibody - Anti-SKP2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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SKP2 Rabbit anti-Human Polyclonal (aa221-425) Antibody
Human
IHC, IHC-P
Unconjugated
250 µl/$485
SKP2 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SKP2 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SKP2 Antibody - Immunohistochemical analysis of SKP2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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SKP2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Bovine, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
SKP2 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using SKP2/p45 antibody.
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SKP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
SKP2 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SKP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SKP2 Antibody - Western blot of 293 cell lysate using SKP2/p45 Antibody
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SKP2 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
SKP2 Antibody - Western blot of Skp2 p45 antibody
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SKP2 Rabbit anti-Human Polyclonal (340-420 aa, C-terminal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SKP2 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SKP2 Rabbit anti-Human Polyclonal (aa1-424) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
SKP2 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SKP2 Rabbit anti-Human Polyclonal (aa1-424) (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
SKP2 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SKP2 Rabbit anti-Human Polyclonal (aa1-424) (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
SKP2 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SKP2 Rabbit anti-Human Polyclonal (aa1-424) (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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SKP2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$564
SKP2 Antibody - IHC of SKP2/p45 (P399) pAb in paraffin-embedded human lung carcinoma tissue.
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SKP2 Rabbit anti-Human Polyclonal (Pro399) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
SKP2 Antibody - Immunohistochemistry of paraffin-embedded mouse liver using SKP2 antibodyat dilution of 1:100 (40x lens).
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SKP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SKP2 Antibody - Immunohistochemistry of paraffin-embedded Mouse liver using SKP2 Polyclonal Antibody at dilution of 1:100 (40x lens).
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SKP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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SKP2 Mouse anti-Human Monoclonal (Concentrated) (SKP2-8D9) Antibody
Human
Flo, IHC, IHC-P
Unconjugated, Concentrated
100 µg/$527
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).