SIX2

SIX homeobox 2

Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

SIX2 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human SIX2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71736

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.1 kDa

Price:

20 µg/$1,107

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Human SIX2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90515

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.1 kDa

Price:

20 µg/$150

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SIX2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112481

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.1 kDa

Price:

100 µg/$494

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Human SIX2 Protein (Recombinant GST) (Full Length) - LS-G32313

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

57.75 kDa

Price:

10 µg/$479; 25 µg/$670

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