SIRT7 / Sirtuin 7

sirtuin 7

NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

SIRT7 / Sirtuin 7 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (2)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Rat (2)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human SIRT7 / Sirtuin 7 Protein (Recombinant GST, N-terminus) (aa191-300) - LS-G62497

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SIRT7 / Sirtuin 7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87682

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.7 kDa

Price:

20 µg/$150

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Human SIRT7 / Sirtuin 7 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70659

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.7 kDa

Price:

20 µg/$1,107

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Rat SIRT7 / Sirtuin 7 Protein (Recombinant His) (aa135-274) - LS-G15597

Source:

E. coli

Tag:

His

Molecular Weight:

17.0 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Rat SIRT7 / Sirtuin 7 Protein (Recombinant His) (aa275-397) - LS-G15592

Source:

E. coli

Tag:

His

Molecular Weight:

15.5 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human SIRT7 / Sirtuin 7 Protein (Recombinant GST) (Full Length) - LS-G33814

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

71.3 kDa

Price:

2 µg/$439

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Human SIRT7 / Sirtuin 7 Protein (Recombinant His-T7) (aa1-400) - LS-G25546

Source:

E. coli

Tag:

His-T7

Molecular Weight:

48.6 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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SIRT7 / Sirtuin 7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101447

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.7 kDa

Price:

100 µg/$494

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