SIRT7 / Sirtuin 7

sirtuin 7

NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

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Products

ELISA Kits (8)

Type

Custom (4)

Development Kit (1)

Sandwich (3)

Target

SIRT7 / Sirtuin 7 (8)

Reactivity

Human (3)

Mouse (1)

Rat (3)

Product Group

DevKit DuoPlus (1)

Format

96-Well Strip Plate (7)

Antibody Pair and Standard (1)

Publications

No (8)

Sample Type

Cell Culture Supernatants (3)

Cell Lysates (3)

Plasma (1)

Serum (1)

Tissue Homogenates (4)

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Human SIRT7 / Sirtuin 7 (Sandwich ELISA) ELISA Kit - LS-F33947

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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DevKit DuoPlus Rat SIRT7 / Sirtuin 7 ELISA Development Kit - LS-F72181

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,328; 1000 Wells/$1,991

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Rat SIRT7 / Sirtuin 7 (Sandwich ELISA) ELISA Kit - LS-F55344

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$893

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Mouse SIRT7 / Sirtuin 7 (Custom ELISA) ELISA Kit - LS-F16155

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human SIRT7 / Sirtuin 7 (Custom ELISA) ELISA Kit - LS-F16156

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat SIRT7 / Sirtuin 7 (Custom ELISA) ELISA Kit - LS-F16157

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Bovine SIRT7 / Sirtuin 7 (Custom ELISA) ELISA Kit - LS-F16158

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human SIRT7 / Sirtuin 7 (Sandwich ELISA) ELISA Kit - LS-F8297

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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