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SIRT5 / Sirtuin 5
sirtuin 5
NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
| Gene Name: | sirtuin 5 |
| Family/Subfamily: | ADP-Ribosyltransferase , not assigned-ADP-Ribosyltransferase |
| Synonyms: | SIRT5, SIR2L5, Sir2-like 5, SIR2-like protein 5, Sirtuin 5, Sirtuin type 5 |
| Target Sequences: | NM_031244 NP_112534.1 Q9NXA8 |
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