SIRT4 / Sirtuin 4

sirtuin 4

Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.

☰ Filters

Products

ELISA Kits (6)

Type

Custom (3)

Sandwich (3)

Target

SIRT4 / Sirtuin 4 (6)

Reactivity

Human (3)

Mouse (1)

Rat (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (5)

Publications

No (6)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (2)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

Select

Rat SIRT4 / Sirtuin 4 (Sandwich ELISA) ELISA Kit - LS-F74130

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$893

Select

Human SIRT4 / Sirtuin 4 (Custom ELISA) ELISA Kit - LS-F14345

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Bovine SIRT4 / Sirtuin 4 (Custom ELISA) ELISA Kit - LS-F14343

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Mouse SIRT4 / Sirtuin 4 (Custom ELISA) ELISA Kit - LS-F14344

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human SIRT4 / Sirtuin 4 (Sandwich ELISA) ELISA Kit - LS-F34044

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human SIRT4 / Sirtuin 4 (Sandwich ELISA) ELISA Kit - LS-F6800

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

Viewing 1-6 of 6 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: ELISA Kits

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.