SIRT4 / Sirtuin 4

sirtuin 4

Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.

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Products

Antibodies (56)

Type

Primary (56)

Target

SIRT4 / Sirtuin 4 (56)

Reactivity

Human (56)

Mouse (25)

Rat (15)

Bovine (3)

Chicken (3)

Chimpanzee (6)

Dog (9)

Drosophila (3)

Gibbon (6)

Horse (6)

Monkey (3)

Pig (6)

Rabbit (3)

Sheep (3)

Xenopus (3)

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Application

IHC (7)

IHC-P (6)

WB (51)

Flo (2)

ELISA (13)

IF (1)

IP (1)

Peptide-ELISA (2)

Host

rabbit (51)

mouse (3)

goat (1)

chicken (1)

Product Group

IHCPlus (2)

Isotype

IgG (13)

IgG1 (3)

IgY (1)

Clonality

monoclonal mc (3)

polyclonal pc (53)

Clone

6A12D7 (1)

6G6D2 (1)

Format

APC (3)

APC Conjugated (4)

Azide-free (1)

Biotin Conjugated (7)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (7)

HRP Conjugated (7)

PE Conjugated (4)

Preservative Free (1)

Unconjugated (21)

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Epitope

aa26-333 (8)

aa28-314 (8)

aa60-255 (8)

aa67-95 (7)

aa216-265 (4)

aa35-84 (4)

aa36-85 (4)

aa1-50 (1)

aa302-314 (1)

Publications

No (56)

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IHC-plus™ SIRT4 / Sirtuin 4 Antibody (aa302-314) LS-B2493

(4.0) Rating

Antibody:

SIRT4 / Sirtuin 4 Goat anti-Human Polyclonal (aa302-314) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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SIRT4 / Sirtuin 4 Antibody (aa216-265) LS-B5590

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa216-265) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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SIRT4 / Sirtuin 4 Antibody (aa216-265, HRP) LS-C427930

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa216-265) (HRP) Antibody

Reactivity:

Dog, Pig, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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SIRT4 / Sirtuin 4 Antibody (aa216-265, Biotin) LS-C427928

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa216-265) (Biotin) Antibody

Reactivity:

Dog, Pig, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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SIRT4 / Sirtuin 4 Antibody (aa216-265, FITC) LS-C427929

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa216-265) (FITC) Antibody

Reactivity:

Dog, Pig, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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SIRT4 / Sirtuin 4 Antibody (aa1-50) LS-C10183

Antibody:

SIRT4 / Sirtuin 4 Mouse anti-Human Monoclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

150 µg/$842

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SIRT4 / Sirtuin 4 Antibody LS-C115842

Antibody:

SIRT4 / Sirtuin 4 Chicken anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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SIRT4 / Sirtuin 4 Antibody LS-C753968

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

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SIRT4 / Sirtuin 4 Antibody (clone 6G6D2) LS-C669320

Antibody:

SIRT4 / Sirtuin 4 Mouse anti-Human Monoclonal (6G6D2) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

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SIRT4 / Sirtuin 4 Antibody (clone 6A12D7) LS-C669359

Antibody:

SIRT4 / Sirtuin 4 Mouse anti-Human Monoclonal (6A12D7) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

Select

SIRT4 / Sirtuin 4 Antibody LS-C782323

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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SIRT4 / Sirtuin 4 Antibody LS-C406787

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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SIRT4 / Sirtuin 4 Antibody (aa67-95) LS-C330137

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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SIRT4 / Sirtuin 4 Antibody (aa67-95, Biotin) LS-C217522

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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SIRT4 / Sirtuin 4 Antibody (aa67-95, FITC) LS-C217523

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SIRT4 / Sirtuin 4 Antibody (aa67-95, Azide-free, HRP) LS-C217524

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

SIRT4 / Sirtuin 4 Antibody (aa67-95, APC) LS-C217521

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SIRT4 / Sirtuin 4 Antibody (aa67-95, PE) LS-C217525

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

SIRT4 / Sirtuin 4 Antibody LS-C780040

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

SIRT4 / Sirtuin 4 Antibody LS-C807208

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

SIRT4 / Sirtuin 4 Antibody (Preservative Free) LS-C815431

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated, Preservative Free

Price:

20 µl/$256; 100 µl/$412

Select

SIRT4 / Sirtuin 4 Antibody LS-C833582

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

SIRT4 / Sirtuin 4 Antibody (aa26-333) LS-C296447

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Mouse Polyclonal (aa26-333) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

Select

SIRT4 / Sirtuin 4 Antibody (aa36-85) LS-C109170

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa36-85) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SIRT4 / Sirtuin 4 Antibody (aa35-84) LS-C109547

Antibody:

SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa35-84) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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