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SIRT1 / Sirtuin 1

sirtuin 1

The SIRT family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. Sirtuins utilize NAD+ as a substrate to catalyze deacetylation of specific acetylated protein and histones. SIRT1 has been shown to be induced by caloric restriction (CR) in several tissues and SIRT1 mediated deacetylase activity attenuates B-amyloid content in the brain during CR. SIRT1 also regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53.

Gene Name: sirtuin 1
Family/Subfamily: ADP-Ribosyltransferase , not assigned-ADP-Ribosyltransferase
Synonyms: SIRT1, SIR2-like protein 1, SIR2alpha, SIR2L1, Sirtuin 1, Sir2-like 1, Sirtuin type 1, HSIR2, HSIRT1
Target Sequences: NM_012238 NP_036370.2 Q96EB6

Publications (8)

1
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. PloS one. 2008 3:e2020. (ICC, IHC) [PubMed:18414679] [PMC:PMC2289879]
2
Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques. Mohan M, Kumar V, Lackner AA, Alvarez X. Journal of immunology (Baltimore, Md. : 1950). 2015 194:291-306. (IF; Rhesus monkey) [Full Text Article] [PubMed:25452565] [PMC:PMC4272908] Related Antibodies: LS-B8356.
3
Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight. Xia N, Weisenburger S, Koch E, Burkart M, Reifenberg G, Förstermann U, Li H. British journal of pharmacology. 2017 174:3443-3453. (WB; Mouse) [Full Text Article] [PubMed:28055105] [PMC:PMC5610154] Related Antibodies: LS-B1564.
4
Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm. Chen HZ, Wang F, Gao P, Pei JF, Liu Y, Xu TT, Tang X, Fu WY, Lu J, Yan YF, Wang XM, Han L, Zhang ZQ, Zhang R, Zou MH, Liu DP. Circulation research. 2016 October;119:1076-1088. (Human) [Full Text Article] [PubMed:27650558] Related Antibodies: LS-B4520.
5
Senescence and autophagy in usual interstitial pneumonia of different etiology. Florian Gallob, Luka Brcic, Sylvia Eidenhammer, Florian Rumpp, Andreas Nerlich, Helmut Popper. Virchows Archiv : an international journal of pathology. 2021 Mar;;478:497-506. [Full Text Article] [PubMed:32851507] [PMC:PMC7973921] Related Antibodies: LS-B1895.
6
The Involvement of Sirtuin 1 Dysfunction in High-Fat Diet-Induced Vascular Dysfunction in Mice. Ning Xia, Gisela Reifenberg, Christian Schirra, Huige Li. Antioxidants (Basel, Switzerland). 2022 March;11: [Full Text Article] [PubMed:35326191] [PMC:PMC8944782] Related Antibodies: LS-B1564.
7
Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model. Yurube T, Hirata H, Kakutani K, Maeno K, Takada T, Zhang Z, Takayama K, Matsushita T, Kuroda R, Kurosaka M, Nishida K. Arthritis research & therapy. 2014 16:R31. [Full Text Article] [PubMed:24472667] [PMC:PMC3979117] Related Antibodies: LS-B1564.
8
Age-dependent increase in miRNA-34a expression in the posterior pole of the mouse eye. Smit-McBride Z, Forward KI, Nguyen AT, Bordbari MH, Oltjen SL, Hjelmeland LM. Molecular vision. 20:1569-78. [Full Text Article] [PubMed:25489229] [PMC:PMC4225137] Related Antibodies: LS-B1564.
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ELISA Kits (17)
Development Kit (1)
Sandwich (14)
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SIRT1 / Sirtuin 1 (17)
Human (7)
Mouse (5)
Rat (5)
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12 x 8-Well Microstrips (1)
96-Well Microplate (4)
96-Well Strip Plate (11)
Antibody Pair and Standard (1)
No (17)
Cell Culture Supernatants (4)
Cell Lysates (6)
Plasma (14)
Serum (14)
Tissue Homogenates (11)
SIRT1 / Sirtuin 1 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SIRT1 / Sirtuin 1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
SIRT1 / Sirtuin 1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SIRT1 / Sirtuin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
SIRT1 / Sirtuin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$834
SIRT1 / Sirtuin 1 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
27.43 - 20000 pg/ml
Chemiluminescent
Cell Lysates, Tissue Homogenates
1 Plate/$1,034
SIRT1 / Sirtuin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SIRT1 / Sirtuin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
SIRT1 / Sirtuin 1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
SIRT1 / Sirtuin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SIRT1 / Sirtuin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SIRT1 / Sirtuin 1 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,276; 1000 Wells/$1,903
SIRT1 / Sirtuin 1 ELISA Kit
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Sandwich
96-Well Microplate
Human
1.23 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$672
SIRT1 / Sirtuin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
SIRT1 / Sirtuin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
34.3 - 2200 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$870
SIRT1 / Sirtuin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$893
SIRT1 / Sirtuin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$854
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).