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SIPR3 / EDG3 / S1P3

sphingosine-1-phosphate receptor 3

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Gene Name: sphingosine-1-phosphate receptor 3
Family/Subfamily: GPCR , Lysophospholipid/Lysosphingolipid
Synonyms: S1PR3, EDG-3, EDG3, LPB3, S1P receptor EDG3, S1P3, S1P receptor Edg-3, S1P receptor 3
Target Sequences: NM_005226 NP_005217.2 Q99500

Publications (3)

1
Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions. Ruben Van Doorn, Jack Van Horssen, Dennis Verzijl, Maarten Witte, Eric Ronken, Bert Van Het Hof, Kim Lakeman, Christine D. Dijkstra, Paul Van Der Valk, Arie Reijerkerk, Astrid E. Alewijnse, Stephan L. M. Peters, Helga E. De Vries. Glia. 2010 58:1465-76. (ICC, IHC-Fr; Human, Hamster) [Full Text Article] [PubMed:20648639] Related Antibodies: LS-B2155.
2
Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases. Gril B, Paranjape AN, Woditschka S, Hua E, Dolan EL, Hanson J, Wu X, Kloc W, Izycka-Swieszewska E, Duchnowska R, Peksa R, Biernat W, Jassem J, Nayyar N, Brastianos PK, Hall OM, Peer CJ, Figg WD, Pauly GT, Robinson C, Difilippantonio S, Bialecki E, Metellus P, Schneider JP, Steeg PS. Nature communications. 2018 July;9:2705. (Human) [Full Text Article] [PubMed:30006619] [PMC:PMC6045677] Related Antibodies: LS-B2155.
3
Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells. van Hooren KW, Spijkers LJ, van Breevoort D, Fernandez-Borja M, Bierings R, van Buul JD, Alewijnse AE, Peters SL, Voorberg J. PloS one. 2014 9:e91346. [Full Text Article] [PubMed:24632890] [PMC:PMC3954688] Related Antibodies: LS-B2155.

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Proteins (5)
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SIPR3 / EDG3 / S1P3 (5)
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GST (2)
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Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (3)
Purified (2)
SIPR3 / EDG3 / S1P3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Human SIPR3 / EDG3 / S1P3 Protein (Recombinant GST, N-terminus) (aa302-378) - LS-G58402
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SIPR3 / EDG3 / S1P3 Protein - 12.5% SDS-PAGE of human S1PR3 stained with Coomassie Blue
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Human SIPR3 / EDG3 / S1P3 Protein (Recombinant GST) (Full Length) - LS-G28291
Wheat Germ Extract
GST
67.32 kDa
2 µg/$439
SIPR3 / EDG3 / S1P3 Protein - 12.5% SDS-PAGE of human EDG3 stained with Coomassie Blue
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Human SIPR3 / EDG3 / S1P3 Protein (Recombinant GST) (Full Length) - LS-G28292
Wheat Germ Extract
GST
68.7 kDa
2 µg/$439
SIPR3 / EDG3 / S1P3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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SIPR3 / EDG3 / S1P3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100484
HEK 293 Cells
Myc-DDK (Flag)
42.1 kDa
100 µg/$494
SIPR3 / EDG3 / S1P3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Human SIPR3 / EDG3 / S1P3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78181
293T Cells
Myc-DDK (Flag)
42.1 kDa
20 µg/$150
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