SIP1

gem (nuclear organelle) associated protein 2

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

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Products

Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

SIP1 (6)

Publications

No (6)

Tag

GST (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human SIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80378

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.4 kDa

Price:

20 µg/$150

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Human SIP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67648

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.4 kDa

Price:

20 µg/$1,107

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Human SIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80376

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28 kDa

Price:

20 µg/$150

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Human SIP1 Protein (Recombinant GST) (Full Length) - LS-G31172

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

58 kDa

Price:

2 µg/$439

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SIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117203

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.4 kDa

Price:

100 µg/$494

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SIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121433

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28 kDa

Price:

100 µg/$494

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