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SIP / TP53INP1
tumor protein p53 inducible nuclear protein 1
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
| Gene Name: | tumor protein p53 inducible nuclear protein 1 |
| Family/Subfamily: | Apoptosis |
| Synonyms: | TP53INP1, p53DINP1, SIP, Teap, TP53DINP1, TP53INP1A, p53-inducible p53DINP1, Stress-induced protein, TP53INP1B |
| Target Sequences: | NM_033285 NP_150601.1 Q96A56 |
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