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SIN3A

SIN3 transcription regulator family member A

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.

Gene Name: SIN3 transcription regulator family member A
Synonyms: SIN3A, DKFZP434K2235, KIAA0700
Target Sequences: NM_015477 NP_056292.1 Q96ST3

Publications (1)

1
Coregulator Sin3a Promotes Postnatal Murine ß-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response. Xiaodun Yang, Sarah M Graff, Cody N Heiser, Kung-Hsien Ho, Bob Chen, Alan J Simmons, Austin N Southard-Smith, Gregory David, David A Jacobson, Irina Kaverina, Christopher V E Wright, Ken S Lau, Guoqiang Gu. Diabetes. 2020 June;69:1219-1231. [Full Text Article] [PubMed:32245798] [PMC:PMC7243292] Related Antibodies: LS-C331555.

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Antibodies (28)
Primary (28)
SIN3A (28)
Human (20)
Mouse (18)
Rat (9)
Bat (3)
Bovine (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Hamster (3)
Horse (3)
Monkey (3)
Pig (3)
IHC (11)
IHC-P (7)
WB (22)
ChIP-Seq (1)
ChrIP (2)
ELISA (8)
ICC (2)
IF (4)
IP (4)
rabbit (28)
Product Group
IHCPlus (1)
IgG (25)
polyclonal pc (28)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Preservative Free (1)
Unconjugated (17)
aa1078-1106 (7)
N-Terminus (5)
aa1-120 (2)
aa1-123 (2)
aa1-50 (2)
Ser832 (1)
aa375-425 (1)
No (27)
Yes (1)
SIN3A Antibody - Immunofluorescence analysis of U2OS cells using SIN3A antibody. Blue: DAPI for nuclear staining.
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SIN3A Rabbit anti-Human Polyclonal (aa1-120) Antibody
Mouse, Human
ChIP-Seq, IF, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
SIN3A Antibody - Anti-SIN3A antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SIN3A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SIN3A Antibody - Anti-SIN3A antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SIN3A Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Dog, Bovine, Pig, Horse, Bat, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
SIN3A Antibody - Anti-SIN3A antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SIN3A Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Dog, Bovine, Pig, Horse, Bat, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
SIN3A Antibody - Anti-SIN3A antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SIN3A Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Dog, Bovine, Pig, Horse, Bat, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
SIN3A Antibody - Immunofluorescent analysis of SIN3A staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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SIN3A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ChrIP, ICC, IF, IP, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
SIN3A Antibody - Immunochemical staining of human SIN3A in human duodenum with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.
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SIN3A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IF, IHC-P
Unconjugated
100 µl/$412
SIN3A Antibody - Immunohistochemistry image of paraffin-embedded human testis tissue at a dilution of 1:100
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SIN3A Rabbit anti-Human Polyclonal (aa1-123) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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SIN3A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
SIN3A Antibody - Immunohistochemistry of paraffin-embedded rat liver using SIN3A antibody at dilution of 1:100 (40x lens).
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SIN3A Rabbit anti-Human Polyclonal (aa1-120) Antibody
Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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SIN3A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ChrIP, IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
SIN3A Antibody - Detection of Human and Mouse Sin3A by Immunohistochemistry. Sample: FFPE sections of human metastatic lymph node (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-Sin3A used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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SIN3A Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
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SIN3A Rabbit anti-Mouse Polyclonal (aa1078-1106) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
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SIN3A Rabbit anti-Mouse Polyclonal (aa1078-1106) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
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SIN3A Rabbit anti-Mouse Polyclonal (aa1078-1106) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
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SIN3A Rabbit anti-Mouse Polyclonal (aa1078-1106) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
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SIN3A Rabbit anti-Mouse Polyclonal (aa1078-1106) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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SIN3A Rabbit anti-Mouse Polyclonal (aa1078-1106) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
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SIN3A Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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SIN3A Rabbit anti-Human Polyclonal (aa375-425) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
SIN3A Antibody - Mouse Sin3a Antibody western blot of mouse NIH-3T3 cell line lysates (35 ug/lane). The Sin3a antibody detected the Sin3a protein (arrow).
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SIN3A Rabbit anti-Mouse Polyclonal (aa1078-1106) Antibody
Mouse
WB
Unconjugated
400 µl/$393
SIN3A Antibody - Detection of Human Sin3A by Immunohistochemistry. Sample: FFPE section of human ovarian tumor. Antibody: Affinity purified rabbit anti-Sin3A used at a dilution of 1:250.
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SIN3A Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IHC
Unconjugated
2.5 µg/$295; 100 µl/$532
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SIN3A Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse
IHC-P
Unconjugated, Preservative Free
100 µl/$412
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SIN3A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$357
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SIN3A Rabbit anti-Human Polyclonal (Ser832) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$357
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).