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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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SIGLEC5 / CD170
sialic acid binding Ig-like lectin 5
SIGLEC5 / CD170 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
| Gene Name: | sialic acid binding Ig-like lectin 5 |
| Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
| Synonyms: | SIGLEC5, CD170 antigen, CD170, CD33 antigen-like 2, OB-binding protein 2, SIGLEC-5, CD33L2, OB-BP2, OBBP2, Obesity-binding protein 2 |
| Target Sequences: | NM_003830 NP_003821.1 O15389 |
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