SHARPIN

SHANK-associated RH domain interactor

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

SHARPIN (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human SHARPIN Protein (Recombinant GST, N-terminus) (aa51-148) - LS-G63294

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SHARPIN Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68790

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.8 kDa

Price:

20 µg/$1,107

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Human SHARPIN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83104

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.8 kDa

Price:

20 µg/$150

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Human SHARPIN Protein (Recombinant GST) (Full Length) - LS-G35540

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.3 kDa

Price:

10 µg/$479; 25 µg/$670

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SHARPIN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109330

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.8 kDa

Price:

100 µg/$494

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