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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SHANK3

SH3 and multiple ankyrin repeat domains 3

Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.

Gene Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: SHANK3, DEL22q13.3, KIAA1650, SPANK-2, PROSAP2, PSAP2, SCZD15
Target Sequences: NM_001080420 NP_001073889.1 Q9BYB0

Filtered by: None
Target
SHANK3 (46)
Reactivity
Human (45)
Mouse (43)
Rat (41)
Bovine (1)
Hamster (1)
Horse (1)
Monkey (1)
Application
IHC (39)
WB (44)
ELISA (4)
ICC (18)
IF (37)
IP (19)
Host
rabbit (9)
mouse (37)
Isotype
IgG (6)
IgG1 (1)
IgG2a (19)
IgG2b (18)
Clonality
monoclonal mc (37)
polyclonal pc (9)
Clone
S367-51 (19)
S69-46 (18)
Format
AP Conjugated (2)
APC Conjugated (2)
Atto 390 Conjugated (2)
Atto 488 Conjugated (2)
Atto 565 Conjugated (2)
Atto 594 Conjugated (4)
Atto 633 Conjugated (2)
Atto 655 Conjugated (2)
Atto 680 Conjugated (2)
Atto 700 Conjugated (2)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (1)
PE (2)
PerCP Conjugated (2)
RPE Conjugated (2)
SA Conjugated (2)
Unconjugated (13)
Epitope
aa840-857 (18)
Internal (1)
aa1475-1525 (1)
aa1691-1741 (1)
Publications
No (46)
Showing 1-25 of 46 results

SHANK3 Antibody (aa840-857, clone S69-46) LS-C153129
Mouse Monoclonal [clone S69-46] (IgG2b) to Human SHANK3
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100µg 1mg/ml  $425.00
Adult Rat hippocampus

SHANK3 Antibody LS-C153697
Rabbit Polyclonal (IgG) to Human SHANK3
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
0.1mg 1mg/ml  $365.00
Immunohistochemistry of SHANK3 in human brain tissue with SHANK3 antibody at 2.5 ug/ml.
Immunofluorescence of SHANK3 in human brain tissue with SHANK3 antibody at 20 ug/ml.

SHANK3 Antibody (Internal) LS-C94888
Rabbit Polyclonal (IgG) to Human SHANK3
Mouse, Rat, Human
IHC, WB
Unconjugated
500µg  $325.00

SHANK3 Antibody (aa1475-1525) LS-C290822
Rabbit Polyclonal (IgG) to Human SHANK3
Mouse, Human
IP, WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human and Mouse SHANK3 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-SHANK3 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

SHANK3 Antibody (aa840-857, clone S69-46) LS-C109032
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Bovine, Rat, Hamster, Horse, Human, Monkey
ICC, IHC, IP, WB
Unconjugated
100µg  $365.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, Biotin) LS-C227765
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Biotin Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, FITC) LS-C227766
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
FITC Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, AP) LS-C227762
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
AP Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, PE, Atto 594) LS-C227768
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
PE, Atto 594 Conjugated
100µg  $405.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, Atto 390) LS-C229885
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 390 Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, Atto 655) LS-C229890
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 655 Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, Atto 633) LS-C229889
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 633 Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, Atto 680) LS-C229891
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 680 Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, Atto 594) LS-C229888
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 594 Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, RPE) LS-C227770
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
RPE Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, Atto 488) LS-C229886
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 488 Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, PerCP) LS-C227769
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
PerCP Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, APC) LS-C227764
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
APC Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, Atto 565) LS-C229887
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 565 Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, Atto 700) LS-C227763
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 700 Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (aa840-857, clone S69-46, SA) LS-C227771
Mouse Monoclonal [clone S69-46] (IgG2b) to Rat SHANK3
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
SA Conjugated
100µg  $395.00
Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK3 Antibody (clone S367-51) LS-C776959
Mouse Monoclonal [clone S367-51] (IgG2a) to Human SHANK3
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100µg 1mg/ml  $365.00
Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
Western Blot analysis of Monkey COS cells transfected with HA-tagged Shank1 showing detection of ~190 kDa SHANK1/SHANK3 protein using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Lane 1: Molecular Weight Ladder. Lane 2: Monkey COS cells transfected with HA-tagged Shank1. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~190 kDa.

SHANK3 Antibody LS-C658344
Rabbit Polyclonal (IgG1) to Human SHANK3
Mouse, Human
ELISA, IHC, WB
Unconjugated
100µg  $560.00

SHANK3 Antibody (clone S367-51, Atto 390) LS-C773381
Mouse Monoclonal [clone S367-51] (IgG2a) to Human SHANK3
Mouse, Rat, Human
IF, IHC, WB
Atto 390 Conjugated
100µg 1mg/ml  $395.00
Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
Western Blot analysis of Monkey COS cells transfected with HA-tagged Shank1 showing detection of ~190 kDa SHANK1/SHANK3 protein using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Lane 1: Molecular Weight Ladder. Lane 2: Monkey COS cells transfected with HA-tagged Shank1. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~190 kDa.

SHANK3 Antibody (clone S367-51, Atto 655) LS-C773383
Mouse Monoclonal [clone S367-51] (IgG2a) to Human SHANK3
Mouse, Rat, Human
IF, IHC, WB
Atto 655 Conjugated
100µg 1mg/ml  $395.00
Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
Western Blot analysis of Monkey COS cells transfected with HA-tagged Shank1 showing detection of ~190 kDa SHANK1/SHANK3 protein using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Lane 1: Molecular Weight Ladder. Lane 2: Monkey COS cells transfected with HA-tagged Shank1. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~190 kDa.
Showing 1-25 of 46 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).