SHANK2 / SHANK

SH3 and multiple ankyrin repeat domains 2

SHANK2 / SHANK is a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.

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Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

SHANK2 / SHANK (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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SHANK2 / SHANK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129199

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

201.1 kDa

Price:

100 µg/$710

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Human SHANK2 / SHANK Protein (Recombinant GST, N-terminus) (aa1034-1124) - LS-G61884

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SHANK2 / SHANK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82802

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

201.1 kDa

Price:

20 µg/$215

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