SH3KBP1 / CIN85

SH3-domain kinase binding protein 1

Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

SH3KBP1 / CIN85 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (6)

Source

293T Cells (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human SH3KBP1 / CIN85 Protein (Recombinant GST) (Full Length) - LS-G33508

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

99.6 kDa

Price:

2 µg/$439

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Human SH3KBP1 / CIN85 Protein (Recombinant GST, N-terminus) (aa224-308) - LS-G62347

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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SH3KBP1 / CIN85 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109148

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.9 kDa

Price:

100 µg/$494

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SH3KBP1 / CIN85 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121071

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.4 kDa

Price:

100 µg/$710

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Human SH3KBP1 / CIN85 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69448

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.4 kDa

Price:

20 µg/$1,107

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Human SH3KBP1 / CIN85 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69447

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.9 kDa

Price:

20 µg/$1,107

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Human SH3KBP1 / CIN85 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84669

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.4 kDa

Price:

20 µg/$215

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Human SH3KBP1 / CIN85 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84671

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.9 kDa

Price:

20 µg/$150

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