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SH2B3 / LNK is a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | SH2B adaptor protein 3 |
Synonyms: | SH2B3, LNK, IDDM20, Lymphocyte adapter protein, SH2B adapter protein 3, SH2B adaptor protein 3 |
Target Sequences: | NM_005475 NP_005466.1 Q9UQQ2 |
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