SGK3

serum/glucocorticoid regulated kinase family, member 3

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.

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Products

Proteins (13)

Type

Over-Expression Lysate (6)

Recombinant (7)

Target

SGK3 (13)

Publications

No (13)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His,N-terminus + GST (1)

His-T7 (2)

Myc-DDK (Flag) (7)

Species

Human (9)

Mouse (1)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (4)

Insect Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human SGK3 Protein (Recombinant GST, N-terminus) (aa1-130) - LS-G62063

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SGK3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71442

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.9 kDa

Price:

20 µg/$1,107

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Human SGK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89780

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.9 kDa

Price:

20 µg/$215

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Human SGK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89782

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.9 kDa

Price:

20 µg/$150

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Human SGK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89783

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.1 kDa

Price:

20 µg/$215

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Mouse SGK3 Protein (Recombinant His-T7) (aa141-368) - LS-G15495

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.9 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human SGK3 Protein (Recombinant His-T7) (aa40-311) - LS-G24439

Source:

E. coli

Tag:

His-T7

Molecular Weight:

35.2 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human SGK3 Protein (Recombinant GST) (Full Length) - LS-G32950

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.3 kDa

Price:

2 µg/$439

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SGK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105618

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.1 kDa

Price:

100 µg/$710

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Human SGK3 Protein (Recombinant His, N-Terminal) - LS-G144066

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

56.9 kDa

Price:

50 µg/$419

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SGK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114380

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.9 kDa

Price:

100 µg/$494

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SGK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120948

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.9 kDa

Price:

100 µg/$710

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Human SGK3 Protein (Recombinant His,N-terminus + GST) (Met1-Leu496) - LS-G139925

Source:

Insect Cells

Tag:

His,N-terminus + GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

85 kDa

Price:

50 µg/$502

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