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Unfortunately, the antibody (ID:143660) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



SGK1 / SGK

serum/glucocorticoid regulated kinase 1

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na+ retention, renal K+ elimination, salt appetite, gastric acid secretion, intestinal Na+/H+ exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na+ channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K+ channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na+/K+ ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na+ transport than isoform 1.

Gene Name: serum/glucocorticoid regulated kinase 1
Family/Subfamily: Protein Kinase , SGK
Synonyms: SGK1, Hsgk, Hsgk1, SGK, Sgk1 variant i3
Target Sequences: NM_005627 NP_005618.2 O00141

Filtered By: None
Target
sgk1-sgk (67)
Reactivity
Human (64)
Mouse (33)
Rat (33)
Bat (10)
Bovine (12)
Chicken (10)
Chimpanzee (6)
Dog (9)
Gibbon (6)
Guinea pig (10)
Hamster (9)
Horse (10)
Monkey (15)
Orangutan (3)
Pig (5)
Rabbit (11)
Sheep (2)
Xenopus (4)
Zebrafish (2)
Application
IHC (12)
IHC-Fr (1)
IHC-P (12)
WB (62)
ELISA (30)
ICC (6)
IF (13)
IP (9)
Host
rabbit (62)
mouse (5)
Isotype
IgG (42)
IgG1,k (2)
IgG2b,k (3)
Clonality
monoclonal mc (6)
polyclonal pc (61)
Clone
11C1069 (1)
1C4 (1)
3C4 (1)
3E3 (1)
3G8 (1)
4D7-G3 (1)
Format
AP Conjugated (2)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (6)
FITC Conjugated (6)
HRP Conjugated (5)
PE Conjugated (2)
Unconjugated (44)
Epitope
aa323-352 (7)
C-Terminus (6)
aa240-289 (4)
aa71-120 (4)
pSer78 (4)
aa145-386 (3)
pSer422 (3)
Internal (1)
Pro73 (1)
aa10-90 (1)
aa180-260 (1)
aa191-431 (1)
aa194-431 (1)
aa27-44 (1)
aa28-55 (1)
aa322-352 (1)
aa350-430 (1)
aa381-430 (1)
aa399-412 (1)
aa41-90 (1)
aa419-431 (1)
pSer255/Thr256 (1)
Publications
No (67)
Showing 1-25 out of 67 results
Anti-SGK1 / SGK Antibody (clone 3E3) IHC-plus™ LS-B5532

Mouse Monoclonal [clone 3E3] (IgG2b,k) to Human SGK1 / SGK
Human
ELISA IF IHC-P WB
Unconjugated
Anti-SGK1 / SGK Antibody (clone 3G8) IHC-plus™ LS-B5535

Mouse Monoclonal [clone 3G8] (IgG1,k) to Human SGK1 / SGK
Human
ELISA IF IHC-P WB
Unconjugated
Anti-SGK1 / SGK Antibody (aa10-90) LS-C386051

Rabbit Polyclonal (IgG) to Human SGK1 / SGK
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
Anti-SGK1 / SGK Antibody (clone 3C4) IHC-plus™ LS-B5534

Mouse Monoclonal [clone 3C4] (IgG2b,k) to Human SGK1 / SGK
Human
ELISA IF IHC-P WB
Unconjugated
Anti-SGK1 / SGK Antibody (clone 1C4) IHC-plus™ LS-B5533

Mouse Monoclonal [clone 1C4] (IgG2b,k) to Human SGK1 / SGK
Human
ELISA IF IHC-P WB
Unconjugated
Anti-SGK1 / SGK Antibody (aa41-90) LS-C117780

Rabbit Polyclonal (IgG) to Human SGK1 / SGK
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
Anti-SGK1 / SGK Antibody (aa419-431) IHC-plus™ LS-B69

Rabbit Polyclonal to Human SGK1 / SGK
Mouse, Rat, Human
ELISA IHC-P WB
Unconjugated
Anti-SGK1 / SGK Antibody LS-C417315

Rabbit Polyclonal to Human SGK1 / SGK
Mouse, Rat, Human
IHC WB
Unconjugated
Anti-SGK1 / SGK Antibody (aa323-352, Biotin) LS-C269205

Rabbit Polyclonal (IgG) to Mouse SGK1 / SGK
Human
ELISA WB
Biotin Conjugated
Anti-SGK1 / SGK Antibody (phospho-Ser78, clone 11C1069) LS-C184121

Rabbit Monoclonal [clone 11C1069] (IgG) to Human SGK1 / SGK
Mouse, Rat, Human, Monkey
IP WB
Unconjugated
Anti-SGK1 / SGK Antibody LS-C499758

Rabbit Polyclonal (IgG) to Human SGK1 / SGK
Mouse, Human
ELISA IF IHC WB
Unconjugated
Anti-SGK1 / SGK Antibody (phospho-Ser255/Thr256) LS-C10109

Rabbit Polyclonal (IgG) to Human SGK1 / SGK
Human
WB
Unconjugated
Anti-SGK1 / SGK Antibody (C-Terminus) LS-C358893

Rabbit Polyclonal to Human SGK1 / SGK
Human, Monkey
ICC IF IHC-P WB
Unconjugated
Anti-SGK1 / SGK Antibody (C-Terminus) LS-C413090

Rabbit Polyclonal to Human SGK1 / SGK
Human, Monkey
ICC IF IHC-P WB
Unconjugated
Anti-SGK1 / SGK Antibody (Internal) LS-C358312

Rabbit Polyclonal to Human SGK1 / SGK
Chicken, Zebrafish, Rat, Rabbit, Mouse, Bovine, Human, Monkey
ICC IF IHC-P WB
Unconjugated
Anti-SGK1 / SGK Antibody LS-C331214

Rabbit Polyclonal (IgG) to Human SGK1 / SGK
Mouse, Rat, Human
IF IHC WB
Unconjugated
Anti-SGK1 / SGK Antibody (clone 4D7-G3) LS-C133430

Mouse Monoclonal [clone 4D7-G3] (IgG1,k) to Human SGK1 / SGK
Human
ELISA IF WB
Unconjugated
Anti-SGK1 / SGK Antibody (C-Terminus) LS-C343649

Rabbit Polyclonal to Human SGK1 / SGK
Human, Monkey
IHC WB
Unconjugated
Anti-SGK1 / SGK Antibody (aa27-44) LS-C313290

Rabbit Polyclonal to Human SGK1 / SGK
Rabbit, Guinea pig, Sheep, Bovine, Pig, Horse, Bat, Human, Monkey
ICC IHC-Fr IHC-P WB
Unconjugated
Anti-SGK1 / SGK Antibody (phospho-Ser422) LS-C380840

Rabbit Polyclonal (IgG) to Human SGK1 / SGK
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
Anti-SGK1 / SGK Antibody (aa350-430) LS-C386052

Rabbit Polyclonal (IgG) to Human SGK1 / SGK
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
Anti-SGK1 / SGK Antibody (aa145-386, Biotin) LS-C420918

Rabbit Polyclonal (IgG) to Mouse SGK1 / SGK
Mouse
ELISA ICC WB
Biotin Conjugated
Anti-SGK1 / SGK Antibody (aa145-386, FITC) LS-C420919

Rabbit Polyclonal (IgG) to Mouse SGK1 / SGK
Mouse
ELISA ICC WB
FITC Conjugated
Anti-SGK1 / SGK Antibody (C-Terminus) LS-C144375

Rabbit Polyclonal to Human SGK1 / SGK
Human
IHC WB
Unconjugated
Anti-SGK1 / SGK Antibody (Pro73) LS-C176468

Rabbit Polyclonal to Human SGK1 / SGK
Mouse, Rat, Human
IF IHC-P WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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