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Shirley, MA 01464
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20700 44th Avenue W
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SGCG / Gamma-Sarcoglycan
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGCG / Gamma-Sarcoglycan is gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).
| Gene Name: | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) |
| Synonyms: | SGCG, 35DAG, DMDA, DMDA1, Gamma sarcoglycan, Gamma-sarcoglycan, LGMD2C, MAM, DAGA4, Gamma-SG, SCARMD2 |
| Target Sequences: | NM_000231 NP_000222.1 Q13326 |
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