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SFTPC / Surfactant Protein C

surfactant protein C

SFTPC / Surfactant Protein C is the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

Gene Name: surfactant protein C
Synonyms: SFTPC, BRICD6, PSP-C, Pulmonary surfactant protein C, SMDP2, SFTP2, SP-C, Surfactant protein C
Target Sequences: NM_003018 NP_003009.2 P11686

Publications (5)

1
Optimization of Variable Ventilation for Physiology, Immune Response and Surfactant Enhancement in Preterm Lambs. Bartolák-Suki E, Noble PB, Bou Jawde S, Pillow JJ, Suki B. Frontiers in physiology. 2017 8:425. (WB; Human) [Full Text Article] [PubMed:28690548] [PMC:PMC5481362]
2
Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung. Yina Du, Geremy C Clair, Denise Al Alam, Soula Danopoulos, Daniel Schnell, Joseph A Kitzmiller, Ravi S Misra, Soumyaroop Bhattacharya, David Warburton, Thomas J Mariani, Gloria S Pryhuber, Jeffrey A Whitsett, Charles Ansong, Yan Xu. American journal of physiology. Lung cellular and molecular physiology. 2019 September;317:L347-L360. [Full Text Article] [PubMed:31268347] [PMC:PMC6766718] Related Antibodies: LS-B10952.
3
Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation. Sandra L Leibel, Rachael N McVicar, Alicia M Winquist, Walter D Niles, Evan Y Snyder. Current protocols in stem cell biology. 2020 September;54:e118. [Full Text Article] [PubMed:32640120] [PMC:PMC7361156] Related Antibodies: LS-B9161.
4
Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia10<sup> University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Pathology, Cologne, Germany12<sup> Dept of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany14<sup> University of Cologne, Faculty of Medicine and University Hospital Cologne, Translation. Dharmesh Hirani , Cristina M Alvira, Soula Danopoulos, Carlos Milla, Michele Donato, Lu Tian, Jasmine Mohr , Katharina Dinger , Christina Vohlen , Jaco Selle, Silke V Koningsbruggen-Rietschel, Verena Barbarino, Christian Pallasch, Stefan Rose-John, Margarete Odenthal, Gloria S Pryhuber, Siavash Mansouri, Rajkumar Savai , Werner Seeger , Purvesh Khatri, Denise Al Alam, Jörg Dötsch, Miguel A Alejandre Alcazar. The European respiratory journal. 2022 Feb;59:2002248. [Full Text Article] [PubMed:34446466] [PMC:PMC8850688] Related Antibodies: LS-B10952.
5
Hedgehog-responsive PDGFRa(+) fibroblasts maintain a unique pool of alveolar epithelial progenitor cells during alveologenesis. Feng Gao, Changgong Li, Soula Danopoulos, Denise Al Alam, Neil Peinado, Sha Webster, Zea Borok, GoleNaz Adeli Kohbodi, Saverio Bellusci, Parviz Minoo. Cell reports. 2022 April;39:110608. [Full Text Article] [PubMed:35385750] [PMC:PMC9199394] Related Antibodies: LS-B10952.
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Proteins (15)
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SFTPC / Surfactant Protein C (15)
No (15)
6His, N-terminus (1)
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GST, N-terminus (2)
His (3)
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SFTPC / Surfactant Protein C Protein - Purified recombinant protein SFTPC was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.8 kDa
20 µg/$1,107
SFTPC / Surfactant Protein C Protein - Recombinant Surfactant Associated Protein C By SDS-PAGE
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E. coli
His,N-terminus + GST
51.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
SFTPC / Surfactant Protein C Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
100 µg/$420; 1 mg/$1,355; 20 µg/$323
SFTPC / Surfactant Protein C Protein - Recombinant Surfactant Associated Protein C By SDS-PAGE
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E. coli
His
12.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
SFTPC / Surfactant Protein C Protein - Recombinant  Surfactant Associated Protein C By SDS-PAGE
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E. coli
His-GST
51.0 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
SFTPC / Surfactant Protein C Protein - Recombinant Surfactant Associated Protein C By SDS-PAGE
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E. coli
His-GST
51.0 kDa
10 µg/$285; 50 µg/$467; 100 µg/$747; 200 µg/$932; 1 mg/$2,058; 500 µg/$1,590; 5 mg/$3,263; 2 mg/$2,246
SFTPC / Surfactant Protein C Protein
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Yeast
His
5.7 kD
1 mg/$1,607; 100 µg/$469; 20 µg/$349
SFTPC / Surfactant Protein C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.8 kDa
20 µg/$150
SFTPC / Surfactant Protein C Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
SFTPC / Surfactant Protein C Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Mammalian Cells
6His, N-terminus
100 µg/$1,009; 50 µg/$723; 20 µg/$431; 1 mg/$3,451
SFTPC / Surfactant Protein C Protein - Recombinant Surfactant Associated Protein C By SDS-PAGE
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E. coli
His
12.3 kDa
10 µg/$285; 50 µg/$467; 100 µg/$747; 200 µg/$932; 1 mg/$2,058; 500 µg/$1,590; 5 mg/$3,263; 2 mg/$2,246
SFTPC / Surfactant Protein C Protein - 12.5% SDS-PAGE of human SFTPC stained with Coomassie Blue
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Wheat Germ Extract
GST
47.41 kDa
10 µg/$479; 25 µg/$670
SFTPC / Surfactant Protein C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.8 kDa
100 µg/$494
SFTPC / Surfactant Protein C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
20.8 kDa
100 µg/$494
SFTPC / Surfactant Protein C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
20.8 kDa
20 µg/$150
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).