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SFTPB / Surfactant Protein B

surfactant protein B

SFTPB / Surfactant Protein B is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene Name: surfactant protein B
Synonyms: SFTPB, 6 kDa protein, PSP-B, SFTP3, SP-B, SFTB3, SMDP1, Surfactant protein B
Target Sequences: NM_000542 NP_000533.3 P07988

Publications (2)

1
Recessive missense LAMP3 variant associated with defect in lamellar body biogenesis and fatal neonatal interstitial lung disease in dogs. Kati J Dillard, Matthias Ochs, Julia E Niskanen, Meharji Arumilli, Jonas Donner, Kaisa Kyöstilä, Marjo K Hytönen, Marjukka Anttila, Hannes Lohi. PLoS genetics. 2020 Mar;16:e1008651. [Full Text Article] [PubMed:32150563] [PMC:PMC7082050] Related Antibodies: LS-B8081.
2
Physiologically variable ventilation in a rabbit model of asthma exacerbation. André Dos Santos Rocha, Roberta Südy, Ferenc Peták, Walid Habre. British journal of anaesthesia. 2020 December;125:1107-1116. [Full Text Article] [PubMed:33070949]

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).