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SFTPB / Surfactant Protein B

surfactant protein B

SFTPB / Surfactant Protein B is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene Name: surfactant protein B
Synonyms: SFTPB, 6 kDa protein, PSP-B, SFTP3, SP-B, SFTB3, SMDP1, Surfactant protein B
Target Sequences: NM_000542 NP_000533.3 P07988

Publications (2)

1
Recessive missense LAMP3 variant associated with defect in lamellar body biogenesis and fatal neonatal interstitial lung disease in dogs. Kati J Dillard, Matthias Ochs, Julia E Niskanen, Meharji Arumilli, Jonas Donner, Kaisa Kyöstilä, Marjo K Hytönen, Marjukka Anttila, Hannes Lohi. PLoS genetics. 2020 Mar;16:e1008651. [Full Text Article] [PubMed:32150563] [PMC:PMC7082050] Related Antibodies: LS-B8081.
2
Physiologically variable ventilation in a rabbit model of asthma exacerbation. André Dos Santos Rocha, Roberta Südy, Ferenc Peták, Walid Habre. British journal of anaesthesia. 2020 December;125:1107-1116. [Full Text Article] [PubMed:33070949]

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Products
Proteins (13)
Over-Expression Lysate (4)
Recombinant (9)
SFTPB / Surfactant Protein B (13)
No (13)
10His, N-terminus + Myc, C-terminus (1)
6His-SUMO, N-terminus (1)
GST (1)
His (2)
His-GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Bovine (1)
Cow (1)
Human (7)
Mouse (1)
Rat (1)
293T Cells (2)
E. coli (6)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Yeast (1)
Purified (5)
Low endotoxin level (1)
SFTPB / Surfactant Protein B Protein - Recombinant Surfactant Associated Protein B By SDS-PAGE
Select
E. coli
His
20.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
SFTPB / Surfactant Protein B Protein - Recombinant Surfactant Associated Protein B By SDS-PAGE
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E. coli
His-T7
28.3 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
SFTPB / Surfactant Protein B Protein - Recombinant  Surfactant Associated Protein B By SDS-PAGE
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E. coli
His-GST, N-terminus
51.1 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
E. coli
10His, N-terminus + Myc, C-terminus
23.8 lDa
1 mg/$1,679; 100 µg/$598; 20 µg/$405
SFTPB / Surfactant Protein B Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
100 µg/$1,128; 20 µg/$721
SFTPB / Surfactant Protein B Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
None
100 µg/$610; 20 µg/$447; 1 mg/$1,761
SFTPB / Surfactant Protein B Protein - Purified recombinant protein SFTPB was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
39.5 kDa
20 µg/$1,107
SFTPB / Surfactant Protein B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.5 kDa
20 µg/$150
SFTPB / Surfactant Protein B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
42.12 kDa
20 µg/$150
SFTPB / Surfactant Protein B Protein - 12.5% SDS-PAGE of human SFTPB stained with Coomassie Blue
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Wheat Germ Extract
GST
68.5 kDa
10 µg/$479; 25 µg/$670
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E. coli
159 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
17.6 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
SFTPB / Surfactant Protein B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
42.12 kDa
100 µg/$494
SFTPB / Surfactant Protein B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
39.5 kDa
100 µg/$494
Viewing 1-13 of 13 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).