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SFTPB / Surfactant Protein B

surfactant protein B

SFTPB / Surfactant Protein B is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene Name: surfactant protein B
Synonyms: SFTPB, 6 kDa protein, PSP-B, SFTP3, SP-B, SFTB3, SMDP1, Surfactant protein B
Target Sequences: NM_000542 NP_000533.3 P07988

Publications (2)

1
Recessive missense LAMP3 variant associated with defect in lamellar body biogenesis and fatal neonatal interstitial lung disease in dogs. Kati J Dillard, Matthias Ochs, Julia E Niskanen, Meharji Arumilli, Jonas Donner, Kaisa Kyöstilä, Marjo K Hytönen, Marjukka Anttila, Hannes Lohi. PLoS genetics. 2020 Mar;16:e1008651. [Full Text Article] [PubMed:32150563] [PMC:PMC7082050] Related Antibodies: LS-B8081.
2
Physiologically variable ventilation in a rabbit model of asthma exacerbation. André Dos Santos Rocha, Roberta Südy, Ferenc Peták, Walid Habre. British journal of anaesthesia. 2020 December;125:1107-1116. [Full Text Article] [PubMed:33070949]

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Products
Antibodies (51)
Primary (51)
SFTPB / Surfactant Protein B (51)
Human (39)
Mouse (13)
Rat (12)
Bovine (2)
Dog (3)
Gibbon (3)
Guinea pig (3)
Pig (10)
IHC (9)
IHC-Fr (2)
IHC-P (7)
WB (51)
ELISA (13)
IP (2)
Peptide-ELISA (1)
rabbit (51)
Product Group
IHCPlus (1)
IgG (22)
polyclonal pc (51)
APC (3)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (6)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (19)
aa111-352 (8)
aa20-193 (8)
aa201-381 (8)
aa129-158 (7)
aa194-243 (4)
Internal (2)
aa1-60 (2)
No (50)
Yes (1)
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SFTPB / Surfactant Protein B Rabbit anti-Pig Polyclonal Antibody
Pig, Human
ELISA, WB
Unconjugated
100 µg/$589
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa1-60) Antibody
Mouse, Bovine, Pig, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$589
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa1-60) Antibody
Mouse, Bovine, Pig, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$862
SFTPB / Surfactant Protein B Antibody - Western blot analysis of extracts of various cell lines, using SFTPB antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 3s.
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$957
SFTPB / Surfactant Protein B Antibody - Western blot of SFTPB / Surfactant Protein B antibody.
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa201-381) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$351
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa129-158) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa129-158) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa129-158) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa129-158) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa129-158) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa129-158) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
SFTPB / Surfactant Protein B Antibody - Anti-Surfactant Protein B / SP-B antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa194-243) (HRP) Antibody
Dog, Guinea pig, Rat, Pig, Gibbon, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
SFTPB / Surfactant Protein B Antibody - Anti-Surfactant Protein B / SP-B antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa194-243) (Biotin) Antibody
Dog, Guinea pig, Rat, Pig, Gibbon, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
SFTPB / Surfactant Protein B Antibody - Anti-Surfactant Protein B / SP-B antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa194-243) (FITC) Antibody
Dog, Guinea pig, Rat, Pig, Gibbon, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
SFTPB / Surfactant Protein B Antibody - Western blot of SP-B antibody
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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SFTPB / Surfactant Protein B Rabbit anti-Pig Polyclonal Antibody
Pig
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
SFTPB / Surfactant Protein B Rabbit anti-Pig Polyclonal (HRP) Antibody
Pig
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
SFTPB / Surfactant Protein B Rabbit anti-Pig Polyclonal (Biotin) Antibody
Pig
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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SFTPB / Surfactant Protein B Rabbit anti-Pig Polyclonal (FITC) Antibody
Pig
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
SFTPB / Surfactant Protein B Antibody - Western blot analysis SP-B using LOVO cells whole cells lysates
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SFTPB / Surfactant Protein B Antibody
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SFTPB / Surfactant Protein B Rabbit anti-Mouse Polyclonal (aa20-193) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$862
SFTPB / Surfactant Protein B Antibody - SFTPB Antibody western blot of HepG2 cell line lysates (35 ug/lane). The SFTPB antibody detected the SFTPB protein (arrow).
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa129-158) Antibody
Human
WB
Unconjugated
400 µl/$393
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).