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SF3B1

splicing factor 3b, subunit 1, 155kDa

Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

Gene Name: splicing factor 3b, subunit 1, 155kDa
Synonyms: SF3B1, Hsh155, MDS, PRP10, PRPF10, SAP 155, Splicing factor 3B subunit 1, SAP155, SF3b155
Target Sequences: NM_012433 NP_036565.2 O75533

Publications (1)

1
Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency. Kyei GB, Meng S, Ramani R, Niu A, Lagisetti C, Webb TR, Ratner L. mBio. 2018 November;9:pii e01423-18. [Full Text Article] [PubMed:30401776] [PMC:PMC6222122] Related Antibodies: LS-C179473.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).