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SETDB2

SET domain, bifurcated 2

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

Gene Name:	SET domain, bifurcated 2
Synonyms:	SETDB2, C13orf4, CLLD8, CLLL8, KMT1F, Lysine N-methyltransferase 1F, SET domain bifurcated 2, SET domain, bifurcated 2
Target Sequences:	NM_031915

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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