Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

SETD7 / SET7

SET domain containing (lysine methyltransferase) 7

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Gene Name: SET domain containing (lysine methyltransferase) 7
Synonyms: SETD7, Lysine N-methyltransferase 7, KIAA1717, SET9, H3-K4-HMTase SETD7, KMT7, SET7, SET7/9
Target Sequences: NM_030648 NP_085151.1 Q8WTS6

Publications (1)

1
SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet ß Cell. Fujimaki K, Ogihara T, Morris DL, Oda H, Iida H, Fujitani Y, Mirmira RG, Evans-Molina C, Watada H. The Journal of biological chemistry. 2015 290:16607-18. (WB; Human) [Full Text Article] [PubMed:25995453] [PMC:PMC4505414]

☰ Filters
Products
Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
SETD7 / SET7 (7)
No (7)
10His-SUMO, N-terminus + Myc, C-terminus (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
SETD7 / SET7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
40.5 kDa
20 µg/$150
SETD7 / SET7 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
SETD7 / SET7 Protein - Purified recombinant protein SETD7 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
40.5 kDa
20 µg/$1,107
SETD7 / SET7 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SETD7 / SET7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
40.5 kDa
100 µg/$494
Select
E. coli
His
41.5 kDa
100 µg/$843
SETD7 / SET7 Protein
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$317; 500 µg/$526; 20 µg/$245
Viewing 1-7 of 7 product results


Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).