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SETD7 / SET7
SET domain containing (lysine methyltransferase) 7
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
| Gene Name: | SET domain containing (lysine methyltransferase) 7 |
| Synonyms: | SETD7, Lysine N-methyltransferase 7, KIAA1717, SET9, H3-K4-HMTase SETD7, KMT7, SET7, SET7/9 |
| Target Sequences: | NM_030648 NP_085151.1 Q8WTS6 |
Publications (1)
1
SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet ß Cell. Fujimaki K, Ogihara T, Morris DL, Oda H, Iida H, Fujitani Y, Mirmira RG, Evans-Molina C, Watada H. The Journal of biological chemistry. 2015 290:16607-18. (WB; Human)
[Full Text Article]
[PubMed:25995453]
[PMC:PMC4505414]
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SETD7 / SET7
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Publications
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(50)
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa131-145) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SETD7 / SET7 Mouse anti-Human Monoclonal (OTI2D10) Antibody
Mouse, Dog, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SETD7 / SET7 Mouse anti-Human Monoclonal (Carrier-free) (OTI2D10) Antibody
Mouse, Dog, Rat, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SETD7 / SET7 Mouse anti-Human Monoclonal (5B4) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
SETD7 / SET7 Mouse anti-Human Monoclonal (S4E5) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa159-189) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SETD7 / SET7 Mouse anti-Human Monoclonal (3D6G11) Antibody
Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
100 µg/$459
SETD7 / SET7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
SETD7 / SET7 Mouse anti-Human Monoclonal (1B3B8) Antibody
Rat, Human, Monkey
ELISA, Flo, WB
Unconjugated
100 µg/$459
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa316-366) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa159-189) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa159-189) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa159-189) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa159-189) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa159-189) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa159-189) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
SETD7 / SET7 Mouse anti-Human Monoclonal (OTI2E3) Antibody
Mouse, Human
Flo, WB
Unconjugated
100 µl/$434
SETD7 / SET7 Mouse anti-Human Monoclonal (Carrier-free) (OTI2E3) Antibody
Mouse, Human
Flo, WB
Unconjugated, Carrier-free
100 µg/$511
SETD7 / SET7 Mouse anti-Human Monoclonal (OTI5B11) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
SETD7 / SET7 Mouse anti-Human Monoclonal (Carrier-free) (OTI5B11) Antibody
Human
Flo, WB
Unconjugated, Carrier-free
100 µg/$511
SETD7 / SET7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$412
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa289-317) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
SETD7 / SET7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
SETD7 / SET7 Rabbit anti-Human Polyclonal (aa316-366) Antibody
Human
IHC, IHC-P
Unconjugated
0.5 µg/$295; 100 µl/$532
SETD7 / SET7 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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