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SERPINA6 / CBG

serpin peptidase inhibitor, clade A, member 6

SERPINA6 / CBG is an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.

Gene Name:	serpin peptidase inhibitor, clade A, member 6
Synonyms:	SERPINA6, Transcortin, CBG, Serpin A6
Target Sequences:	NM_001756 NP_001747.2 P08185

Publications (2)

New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver. Gulfo J, Ledda A, Gea-Sorlí S, Bonjoch L, Closa D, Grasa M, Esteve M. PloS one. 2016 11:e0146497. (IHC; Mouse) [Full Text Article] [PubMed:26741814] [PMC:PMC4704799]

Corticosteroid-Binding Globulin is expressed in the adrenal gland and its absence impairs corticosterone synthesis and secretion in a sex-dependent manner. Gulfo J, Castel R, Ledda A, Romero MDM, Esteve M, Grasa M. Science advances. 2019 September;9:14018. [Full Text Article] [PubMed:31570737] [PMC:PMC6769001]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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