SERPINA5 / PCI

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

SERPINA5 / PCI (8)

Publications

No (8)

Tag

10His, N-terminus (1)

6His, C-terminus (2)

6His, N-terminus (1)

GST (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (1)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Human SERPINA5 / PCI Protein (Recombinant 6His, N-terminus) (aa43-406) - LS-G25283

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

44.7 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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SERPINA5 / PCI Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123074

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

100 µg/$494

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Mouse SERPINA5 / PCI Protein (Recombinant 10His, N-terminus) (Full Length) - LS-G136853

Source:

Baculovirus

Tag:

10His, N-terminus

Molecular Weight:

45.3 kDa

Price:

100 µg/$1,164; 20 µg/$475; 1 mg/$2,187

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Human SERPINA5 / PCI Protein (Recombinant GST) (Full Length) - LS-G29641

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.64 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SERPINA5 / PCI Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78093

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

20 µg/$150

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Human SERPINA5 / PCI Protein (Recombinant His) - LS-G639

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human SERPINA5 / PCI Protein (Recombinant 6His, C-terminus) (His20-Pro406) - LS-G140384

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

44.7 kDa

Price:

10 µg/$317; 50 µg/$524

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Human SERPINA5 / PCI Protein (Recombinant 6His, C-terminus) (His20-Pro406) - LS-G39039

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

44.7kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585

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