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SEPX1 / Selenoprotein R
methionine sulfoxide reductase B1
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
| Gene Name: | methionine sulfoxide reductase B1 |
| Synonyms: | MSRB1, Selenoprotein R, Selenoprotein X, 1, SELR, SepR, HSPC270, Selenoprotein X, SELX, SEPX1 |
| Target Sequences: | NM_016332 NP_057416.1 Q9NZV6 |
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