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SEPT9 / Septin 9 is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.
Gene Name: | septin 9 |
Family/Subfamily: | Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806 |
Synonyms: | SEPT9, AF17q25, Ov/Br septin, PNUTL4, KIAA0991, Septin 9, Septin D1, MLL septin-like fusion, MLL septin-like fusion protein, SINT1, MSF, MSF1, Ovarian/Breast septin, SeptD1, Septin-9 |
Target Sequences: | NM_006640 NP_006631.2 Q9UHD8 |
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