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SEPHS2 is an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. Genes encoding selenocysteine contain a stem-loop secondary structure in their 3' UTR called a selenocysteine insertion sequence (SECIS) element. The protein encoded by this gene contains a selenocysteine residue in its predicted active site. There is a pseudogene for this gene on chromosome 5.
Gene Name: | selenophosphate synthetase 2 |
Synonyms: | SEPHS2, Selenophosphate synthase 2, SPS2b, Selenium donor protein 2, Selenophosphate synthetase 2, SPS2, Selenide, water dikinase 2 |
Target Sequences: | NM_012248 NP_036380.2 Q99611 |
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