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SENP5
SUMO1/sentrin specific peptidase 5
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).
| Gene Name: | SUMO1/sentrin specific peptidase 5 |
| Family/Subfamily: | Protease , Cysteine C48 |
| Synonyms: | SENP5, Sentrin-specific protease 5, FKSG45 |
| Target Sequences: | NM_152699 Q96HI0 Q96HI0 |
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